Mevalonate pathway, selenoproteins, redox balance, immune system, Covid-19: Reasoning about connections

Redox active motifs in selenoproteins.

Selenoproteins use the rare amino acid selenocysteine (Sec) to act as the first line of defense against oxidants, which are linked to aging, cancer, and neurodegenerative diseases. Many selenoproteins are oxidoreductases in which the reactive Sec is connected to a neighboring Cys and able to form a ring. These Sec-containing redox motifs govern much of the reactivity of selenoproteins. To study...

COVID-19: The potential role of nutritional deficiencies, global climatic changes, and immune system dysfunction

Nitroso-redox balance in the cardiovascular system.

The results with the combination therapy were markedly positive, meeting the composite end point of the trial, which included death from any cause, a first hospitalization for heart failure, and quality-oflife measures. In addition, there was an impressive reduction in the rate of death from any cause of approximately 45 percent, leading to an early termination of the study. This trial raises f...

Investigating People’s Anxieties and Concerns About COVID-19

Background: In January 2020, the World Health Organization (WHO) declared the COVID-19’s outbreak as an international public health emergency. In March 2020, WHO evaluation showed that COVID-19 could be considered a pandemic disease. Nowadays, the spread of COVID-19 threatens all aspects of human living conditions. In this regard, the objectives of this research are to investigate the anxieties...

Reasoning about nonlinear system identification

System identification is the process of deducing a mathematical model of the internal dynamics of a system from observations of its outputs. The computer program PRET automates this process by building a layer of artificial intelligence (AI) techniques around a set of traditional formal engineering methods. PRET takes a generate-and-test approach, using a small, powerful meta-domain theory that...